Life Science Practical Magic

The keto diet can actually help 'reseal' the protective barrier around the spinal cord that gets wrecked by Multiple Sclerosis.

March 25, 2026

Original Paper

A KETOGENIC DIET PROMOTES BLOOD-SPINAL CORD BARRIER RESEALING TO DECREASE SPINAL CORD IMMUNE CELL INFILTRATION IN A PRECLINICAL MODEL OF MULTIPLE SCLEROSIS.

Plafker, K. S.; Walton, D. A.; Pezant, N.; Plafker, S. M.

bioRxiv · 10.64898/2026.02.06.704406

The Takeaway

In Multiple Sclerosis, the wall between the blood and the spinal cord becomes leaky, allowing rogue immune cells to enter and attack the nervous system. This study found that a specific high-fat diet triggers the body to quickly repair this physical breach, locking out damaging cells and helping to restore motor function.

From the abstract

We previously reported that a medium chain triglyceride and {omega}-3 fatty acid rich ketogenic diet (KD) restores vision and motor functions to mice undergoing experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis (MS). The studies reported here use immune cell profiling to identify the mechanisms underlying this efficacy. We show here that the diet dramatically reduces the infiltration of CD45HI immune cells into the spinal cords of EAE mice when fed for 2