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Paradigm Challenge  /  Biology

H5N1 bird flu needs only 10 units of virus to infect a dairy cow through its udders, yet it refuses to spread through normal close contact.

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Current containment strategies assume the bird flu outbreak in cattle is spreading through the air or shared water. Experimental tests show that while the virus is incredibly efficient at infecting mammary glands, it does not move between cows through milking equipment or respiratory droplets. This creates a massive mystery because the virus is clearly moving through farms in the real world. The tiny dose required for infection suggests that even trace amounts of contaminated material can trigger an outbreak. We are missing the primary way this virus moves, which makes it nearly impossible to contain right now.

Original Paper

Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers

Carolyn Lee, Natalie N. Tarbuck, Hannah J. Cochran, Bryant M. Foreman, Patricia Boley, Saroj Khatiwada, Alok Dhakal, Khadijat O. Adefaye, Jennifer Schrock, Mohammad Jawad Jahid, Thamonpan Laocharoensuk, Raksha Suresh, Olaitan Shekoni, Erika Stevens, Sara Dolatyabi, Christina Sanders, Elizabeth Ohl, Devra Huey, Juliette Hanson, Renukaradhya Gourapura, Richard J. Webby, Cody J. Warren, Scott P. Kenney, Andrew S. Bowman

research_square  ·  rs-6900680

Abstract The discovery that highly pathogenic avian influenza A(H5N1) virus exhibits a strong tropism for the bovine mammary gland1–4 represents a major shift in our understanding of influenza A virus host range and tissue specificity. We conducted a comprehensive series of experimental studies with influenza A(H5N1) B3.13 genotype in lactating dairy cattle to address several key questions related to the viral dose required to establish infection, routes of exposure that lead to transmission, an