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Nature Is Weird  /  Biology

Medaka fish have a specific section of DNA that has refused to change for 15 million years while the rest of their genome evolved at high speed.

Centromeres are the structural hubs of chromosomes and are usually the most volatile, fast-changing parts of any genome. These fish possess a unique set of satellite arrays that remain frozen in time even as new species are born. This stability acts as a biological anchor that prevents the genetic chaos normally associated with rapid evolution. Finding a permanent landmark in such a chaotic environment changes how we understand the birth of new species. It suggests that some parts of life are hard-coded to resist change no matter what the environment demands.

Original Paper

Centromere methylation and genome divergence during vertebrate speciation

Shinichi Morishita, Yoshihiko Suzuki, Kazuki Ichikawa, Yusuke Inoue, Chie Owa, Haruka Kobayashi, Kenji Morikami, Ryohei Nakamura, Takafumi Ikeda, Manabu Fujie, Mayumi Kawamitsu, Nana Arakaki, Eugene Myers, Hiroyuki Aburatani, Yusuke Takehana, Masaru Matsuda, Kiyoshi Naruse, Shigehiro Kuraku, Hiroyuki Takeda

research_square  ·  rs-6858750

Abstract Medaka fish (Oryzias latipes) is a small freshwater teleost widely used as a model organism in developmental and evolutionary biology. Here, we generated complete and near-complete genome assemblies of three inbred medaka strains currently undergoing speciation after geographic separation. Fully resolved centromeres reveal both conserved and divergent satellite repeats shaped during speciation. Notably, short and distinct satellite arrays flanked by large and homogenized arrays are hypo