Doctors can now smell physical pain in a patient's breath by detecting a specific metabolic signature that appears when they are hurting.
Pain is famously difficult to measure because it relies entirely on a patient's subjective report. Researchers have identified a specific set of metabolic shifts that show up in exhaled breath the moment a person experiences pain. Using this signature, they were able to accurately identify pain states with a high degree of precision. This objective pain meter could revolutionize how we treat babies, people with dementia, or patients in comas who cannot speak for themselves. It takes the guesswork out of pain management and ensures that patients receive the right amount of medication exactly when they need it.
Pain induces a rapid characteristic metabolic signature detectable in breath
research_square · rs-6048423
Abstract The objectification of pain presents a significant clinical challenge, particularly in children, elderly individuals, patients with disabilities and unconscious patients. It is critically important to accurately assess pain in these populations due to the heightened risk of undertreatment. Using the cold pressor test (CPT) as a pain induction model, we combined real-time breath metabolomics with pathway analysis to uncover metabolic shifts. Exhaled breath was analyzed in a discovery coh