A protein that stops cancer in the blood can actually help cancer grow if it shows up in the colon.
The protein known as SHIP1 has been widely celebrated as a powerful tumor suppressor in leukemia. New research reveals that this same protein switches roles and acts as an oncogene when it is active in colorectal cancer. Instead of stopping the disease, it actively promotes the growth and survival of colon tumors. This Jekyll and Hyde behavior shows that a protein's function is entirely dependent on the organ it is in. It serves as a warning that cancer treatments targeting specific proteins must be tailored to the exact location of the tumor.
Oncogenic function of the Inositol 5-phosphatase SHIP1 in colorectal cancer
SSRN · 6730003
Oat bran is a nutrient-dense by-product rich in phenolic compounds, but their bioaccessibility and functionality are limited by its compact tissue structure. Three particle sizes at medium (MOB), fine (FOB) and superfine of oat bran (SOB) were characterized by its structural properties, phenolic release and bioactivity. Superfine milling increased water retention capacity, accompanied by decreased pore size and higher soluble dietary fiber content. It also promoted the release of free and bound