Neurons communicate through a rapid exchange of electrons rather than moving salt ions around.
The established consensus for decades has been that brain signals rely on charged ions flowing through tiny gates in a cell membrane. The murburn-thermodynamic model suggests that redox-mediated electronic dynamics are the true engine behind every thought and movement. If this theory holds, the fundamental physics of the human brain is more like a solid-state computer than a chemical pump. This shift moves the focus from liquid flux to thermodynamic electron transfer as the primary driver of life. Changing this foundational understanding would rewrite the search for treatments for every neurological disease from Alzheimer's to epilepsy.
Neuronal electricality founded in murburn-thermodynamic principles: 2. Comparisons, evidenced explanations, and predictions
arXiv · 2605.00014
The analyses presented herein demonstrate that neuronal electrical activity can be consistently interpreted as a manifestation of murburn redox-mediated electronic dynamics rather than as a process fundamentally driven by transmembrane ionic flux. By integrating comparison with established models, quantitative predictions, and diverse experimental observations, the murburn framework emerges as a unified and chemically grounded description of excitability. A key strength of the model lies in its