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Nature Is Weird  /  Biology

The fundamental energy molecules that power every living cell on Earth likely formed spontaneously from minerals in deep-sea volcanic vents.

Life requires a specific process called phosphorylation to store and move energy. A mineral called native palladium found in hydrothermal vents can turn common phosphite into reactive phosphate. This reaction happens without any enzymes or complex biological machinery and creates the precursors for molecules like ADP and ATP. This suggests that the chemical battery of life was already running before the first cell ever existed. Deep-sea vents may have acted as a giant natural laboratory that pre-packaged the ingredients for the first organisms.

Original Paper

Hydrothermal origin of metabolic phosphorylation

Schlikker, M. L.; Hoffmann, N. K.; Metzger, S.; Moral-Pombo, J.; Tuysuz, H.; Martin, W. F.

bioRxiv  ·  10.64898/2025.12.19.695421

Phosphate is central to modern bioenergetics and to all theories for the origin of life. How phosphate entered metabolism is unknown, though microbial physiology and geochemical environments can provide important clues. Some bacteria obtain electrons and energy from phosphite (HPO32-), a reduced form of phosphate (HPO42-), that naturally occurs in serpentinizing (H2-producing) hydrothermal systems. Here we show that the insoluble, solid state catalyst native palladium, which is naturally deposit