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Nature Is Weird  /  Biology

Some proteins are just "architectural scaffolding" that physically hold other enzymes in place to speed up chemical reactions.

In the creation of alkaloids, certain MDR proteins do not actually perform any chemistry themselves. Instead, they act as physical supports that organize other enzymes into a specific 3D shape. This arrangement allows reactive chemicals to be passed directly from one enzyme to the next without leaking away. It makes the entire biological factory much more efficient and allows for a wider variety of complex molecules to be built. This reveals a new level of cellular organization where doing nothing is actually the most important job.

Original Paper

Geissoschizine scaffolding enzymes shape monoterpene indole alkaloid biosynthesis

Brelu-Brelu, D.; Lezin, E.; Miller, E. P.; Zamar, D.-L.; Durand, M.; Pattanaik, S.; Patra, B.; Gautron, N.; Birer Williams, C.; Perrot, T.; Lanoue, A.; Oudin, A.; Le Pogam, P.; Beniddir, M. A.; Giglioli-Guivarc'h, N.; St-Pierre, B.; Massiot, G.; Papon, N.; Yuan, L.; Li, S.; Sun, C.; Besseau, S.; Courdavault, V.

bioRxiv  ·  10.64898/2026.04.29.721795

For decades, medicinal plants have been an invaluable source of therapeutics for human health. Among plant specialized metabolites, monoterpene indole alkaloids (MIAs) display remarkable chemical diversity and potent bioactivities, including anticancer properties. While the biosynthetic pathways leading to major MIAs such as vincristine, vinblastine, and camptothecin have been extensively studied, the mechanisms regulating metabolic flux within these pathways remain poorly understood. Here, we u