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Collision  /  Psychology

A single broken circuit in the brain's reward center causes both early life obesity and chronic impulsivity.

Slow maturation in the nucleus accumbens shell creates a shared genetic vulnerability for weight gain and poor self-control. This specific inhibitory-control circuit is supposed to develop as children age to help them manage their impulses. When this growth is blunted, the brain cannot effectively regulate the urge to eat or act on whim. It proves that obesity and impulsivity are not separate character flaws, but two symptoms of the same neurological delay. Targeting this one specific brain region could provide a single medical solution for two very different health crises.

Original Paper

Blunted maturation of inhibitory control circuits in the NAC-shell underlies genetic vulnerability to early-life obesity and impulsivity

Sandini, C.; Delavari, F.; Reich, N.; Forrer, S.; Imparato, A.; Kojovic, N.; Latreche, C.; Saccaro, L. F.; Parlatini, V.; Cortese, S.; Piguet, C.; Schneider, M.; Eliez, S.; Van de Ville, D.

medRxiv  ·  10.64898/2026.04.28.26351915

Obesity and behavioral impulsivity are highly heritable traits that share overlapping genetic risk and often co-occur in childhood. This study investigates whether maturation of the nucleus accumbens shell (NAC-shell) inhibitory-control circuit mediates shared vulnerability to both traits. Using state-of-the-art dynamic fMRI, we mapped NAC-shell development across 460 longitudinal assessments from childhood to adulthood, in 136 healthy controls and 126 individuals with 22q11.2 deletion syndrome