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Practical Magic  /  Biology

A shelf-stable oxygen pill could someday replace the need for blood transfusions during emergency surgeries.

Traditional blood transfusions require matching blood types and keeping the supply refrigerated, which is often impossible in emergencies. This conceptual framework proposes an oral supplement based on perfluorocarbons that carries oxygen directly through the digestive system. Once swallowed, the complex creates a systemic reserve of oxygen that the body can draw from if the heart or lungs are struggling. It would be blood-group independent, meaning it could be given to anyone instantly regardless of their type. This liquid breath in pill form would fundamentally change how we handle trauma and massive blood loss on the fly.

Original Paper

Oral Perfluorocarbon-Based Oxygen Carrier: A Conceptual Framework for a Perfluorononane–β-Cyclodextrin Inclusion Complex as a Blood-Group-Independent Systemic Oxygen Supplement

Pattrick Chen, Chaiyapat Chuenglertsiri

ChemRxiv  ·  10.26434/chemrxiv.15002858/v1

Current allogeneic blood transfusion is constrained by ABO/Rh compatibility requirements, donor dependency, cold-chain logistics, and limited erythrocyte shelf life. Perfluorocarbon (PFC) compounds dissolve molecular oxygen efficiently and are immunologically inert, yet existing PFC preparations require intravenous administration, limiting pre-hospital and resource-constrained deployment. Here we describe a conceptual oral formulation comprising Perfluorononane (PFN, C 9 F 20 ) encapsulated with